Regadenoson is a better myocardial vasodilator than dipyridamole in normal volunteers, but the data is less compelling in patients
نویسندگان
چکیده
Methods Forty patients with normal coronaries/minimal stenosis on coronary CT angiography had also undergone vasodilator stress MR (regadenoson n=20, dipyridamole n=20). Seventeen healthy normal volunteers with Framingham score less than 1% underwent vasodilator stress testing with regadenoson and dipyridamole in two separate studies using a SSFP sequence. Stress imaging was done 70 seconds post regadenoson injection and 4 minutes after completing the dipyridamole infusion. All patients and volunteers received aminophylline after stress imaging. Rest imaging was done 20 minutes later. MBF in ml/min/g and Myocardial perfusion reserve (MPR) were quantified using a fully quantitative model constrained deconvolution (MCD).
منابع مشابه
Regadenoson and adenosine are equivalent vasodilators and are superior than dipyridamole- a study of first pass quantitative perfusion cardiovascular magnetic resonance
BACKGROUND Regadenoson, dipyridamole and adenosine are commonly used vasodilators in myocardial perfusion imaging for the detection of obstructive coronary artery disease. There are few comparative studies of the vasodilator properties of regadenoson, adenosine and dipyridamole in humans. The specific aim of this study was to determine the relative potency of these three vasodilators by quantif...
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متن کاملRegadenoson in the detection of coronary artery disease
Myocardial perfusion studies use either physical exercise or pharmacologic vasodilator stress to induce maximum myocardial hyperemia. Adenosine and dipyridamole are the most commonly used agents to induce coronary arterial vasodilation for myocardial perfusion imaging. Both cause frequent undesirable side-effects. Because of its ultrashort half-life, adenosine must be administered by constant i...
متن کاملRisk stratification by regadenoson stress MRI in patients with known or suspected coronary artery disease
Background With the expanding use of vasodilator stress CMR, there has been a parallel rise in the use of regadenoson as a pharmacological stress agent. To date, however, prognostic data for stress CMR has focused on the use of adenosine or dipyridamole while prognostic data regarding the use of regadenoson is limited. We therefore sought to identify the prognostic value of regadenoson vasodila...
متن کاملOptimal timing of rest perfusion with regadenoson stress testing - normal volunteer study of quantitative MRI perfusion
Methods Seventeen healthy normal volunteers with Framingham score less than 1% underwent vasodilator stress testing with regadenoson using a SSFP sequence. Rest imaging (Rest 1) was performed initially. Twenty minutes later, regadenoson 400mcg was administered as a 10 second injection with saline flush. Stress imaging was done 70 seconds after the injection. All volunteers received aminophyllin...
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